After residing together with her grandparents, younger Sneha is relocating to dwell together with her father Hareendran and her step-mom Anjali, a trans lady, who extends her love and take care of Sneha. Sneha understands extra about Anjali and turns into in awe of the life the latter has been main. The movie focuses on the plight of a trans lady who needed to dwell as a spouse of an bizarre man. ‘Antharam’ offers with the internal conflicts, heat, trauma and joyous moments within the lives of a trans lady, a lady and a person residing below the identical roof.