As Emily struggles to slot in at house and at college, she discovers a small pink pet who's destined to develop into her finest good friend. When Clifford magically undergoes one heck of a progress spurt, turns into a big canine and attracts the eye of a genetics firm, Emily and her Uncle Casey must battle the forces of greed as they go on the run throughout New York Metropolis. Alongside the best way, Clifford impacts the lives of everybody round him and teaches Emily and her uncle the true that means of acceptance and unconditional love.