As a toddler dwelling in Africa, Jill Younger noticed her mom killed whereas defending wild gorillas from poachers led by Andrei Strasser. Now an grownup, Jill cares for an orphaned gorilla named Joe -- who, resulting from a genetic anomaly, is 15 toes tall. When Gregg O'Hara arrives from California and sees the animal, he convinces Jill that Joe can be most secure at his wildlife refuge. However Strasser follows them to the U.S., intent on capturing Joe for himself.