Primatologist Davis Okoye shares an unshakable bond with George, the terribly clever, silverback gorilla who has been in his care since delivery. However a rogue genetic experiment gone awry mutates this mild ape right into a raging creature of monumental dimension. To make issues worse, it’s quickly found there are different equally altered animals. As these newly created alpha predators tear throughout North America, destroying every thing of their path, Okoye groups with a discredited genetic engineer to safe an antidote, combating his method via an ever-changing battlefield, not solely to halt a world disaster however to avoid wasting the fearsome creature that was as soon as his good friend.