Rappadikalude Gatha is woven round Gatha, a younger lady who finds happiness in medication and music. She marries a health care provider of humble indisposition. Their marriage runs into problem however, after a number of traumatic experiences, the couple are reconciled. The movie is a pointy indictment of society, its awry priorities, on the frustrations of the youth, their disappointments, and the way kids get hooked to medication.