For Tammy, a burger-joint worker, a nasty day retains getting worse. She wrecks her automobile, loses her job and finds that her husband has been untrue. It is time for Tammy to hit the highway, however with out cash or transportation, her choices are restricted. Her solely alternative is a highway journey along with her hard-drinking grandmother, Pearl, who has a automobile, money and an itch to see Niagara Falls. It isn't the escape Tammy had in thoughts, however it might be what she wants.