Ray Tango and Gabriel Money are narcotics detectives who, whereas each being extraordinarily profitable, cannot stand one another. Crime Lord Yves Perret, livid on the lack of revenue that Tango and Money have triggered him, frames the 2 for homicide. Caught with the homicide weapon on the scene of the crime, the 2 don't have any alibi. Thrown into jail with many of the criminals they helped convict, it seems that they will need to belief one another if they're to clear their names and catch the evil Perret.