In the midst of a routine patrol, officer Daniel Carter occurs upon a blood-soaked determine limping down a abandoned stretch of street. He rushes the younger man to a close-by rural hospital staffed by a skeleton crew, solely to find that sufferers and personnel are remodeling into one thing inhuman. Because the horror intensifies, Carter leads the opposite survivors on a hellish voyage into the subterranean depths of the hospital in a determined bid to finish the nightmare earlier than it is too late.